The levels of PM 2.5, PM 10, SO 2, and NO 2 were significantly related to the number of admissions for RA-ILD.
In the 5-year study, there were 221 hospitalizations for RA-ILD in Jinan city. This time-series study was performed from January 1 st, 2015 to December 31 st, 2019.
The relationships between ambient air pollutant concentrations, including PM 2.5, PM 10, sulfur dioxide (SO 2), ozone (O 3), and nitrogen dioxide (NO 2), and monthly hospitalizations for RA-ILD were studied by employing a general linear model with a Poisson distribution.
Our research aimed to explore whether there is a correlation and to estimate how the association was distributed across various lags in Jinan, China. Little is known within the medical community about the impact of air pollution on hospital admissions due to rheumatoid arthritis associated with interstitial lung disease (RA-ILD).
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This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Shandong Medical and Health Technology Development (2017WS185).Ĭonflicts of Interest The authors declare no conflict of interest. 2022 101:19(e29309).įunding The Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province (BS2010YY054), Shandong Medical and Health Technology Development (2014WS0361). Observational studies: Ambient air pollution and hospitalization for RA-ILD in a heavily polluted city in China.
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How to cite this article: Liu B, Sun G, Liu Y, Hou Y. 16766 Jingshi Road, Jinan, Shandong, China (e-mail: )Ībbreviations: anti-MAA = anti-malondialdehyde-acetaldehyde adduct, CI = Confidence interval, COPD = chronic obstructive pulmonary disease, EPA = the Environmental Protection Authority, ER = Excess risks, GAM = the generalized additive model, HIS = the Hospital Information System, HRCT = high-resolution CT, IL-1 = interleukin-1, IL-6 = interleukin-6, ILD = Interstitial lung disease, NF-kB = nuclear factor kappa-B, NO 2 = Nitrogen dioxide, O 3 = Ozone, RA = Rheumatoid Arthritis, RA-ILD = Rheumatoid arthritis associated with Interstitial lung Disease, SO 2 = Sulfur dioxide, Th1 = T helper lymphocyte type 1, TNF-α = tumor necrosis factor alpha. ∗Correspondence: Yanfeng Hou, Department of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong medicine and Health Key Laboratory of Rheumatism. 16766 Jingshi Road, Jinan, Shandong, China. ADepartment of Rheumatology, Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaīDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicineĬDepartment of Rheumatology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaĭDepartment of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong medicine and Health Key Laboratory of Rheumatism.
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